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A High Survival Capacity

Thanks to its sporulated form, B. subtilis Rosell®-179 can survive high acidic environment and resists to high concentrations of bile.

  • A study performed using in vitro model of the upper gastrointestinal tract (IViDiS) showed that, unlike most subtilis strains, which are revived from their sporulated forms in the small intestine, B. subtilis Rosell®-179, when ingested with a meal, is able to germinate in the stomach, thanks to the buffering capacity of the meal.
  • Also, in a randomized, double-blind, placebo-controlled trial in healthy adults [Hanifi 2015], B. subtilis Rosell®-179 has demonstrated to survive passage through the human gastro-intestinal tract and was well tolerated by participants.

Promising results in metabolic health

B. subtilis Rosell®-179 demonstrated its ability to activate bile acids metabolism in a double-blind, placebo-controlled crossover study [Culpepper 2019] in healthy adults with a high waist circumference. B. subtilis Rosell®-179 has shown to increase plasma deconjugated bile acids and plasma secondary bile acids in adults with a BMI ≥30.