Cerebiome® Scientifically Proven Probiotic for Mental Health

Discover Cerebiome^®: The Most Documented Psychobiotic

While ongoing research continues to explore the role of bacteria in the gut-brain axis, the Rosell® Institute for Microbiome and Probiotics by Lallemand initiated the first clinical studies on the microbiota-gut-brain axis in healthy adults using Cerebiome, a scientifically documented probiotic formula designed by Lallemand Health Solutions to support mental health. It combines two unique strains with complementary effect: Lactobacillus helveticus Rosell®-52 and Bifidobacterium longum Rosell®-175, at a concentration of 3 billion CFU per day.

9+Clinical Studies

11+Mechanistic Studies

8 Modes of Action on the Brain-Gut Axis

To Support a Healthy Response to Day-to-Day Stress Management

Since the early 2000’s, Cerebiome has been studied for mental well-being in humans in nine clinical studies and eleven pre-clinical studies, highlighting eight mechanisms of action on the gut-brain axis. Pioneering the field, the first two clinical studies [Diop et al. 2008 & Messaoudi et al. 2010] showed for the first time benefits of probiotics on stress-induced gastrointestinal symptoms and on occasional psychological stress in otherwise healthy adults with occasional stress.

Now, Cerebiome provides benefits not only in stress and gut comfort but also in holistic well-being with improvement in physiological parameters such as sleep quality, which is perfectly aligned with the evolving needs of consumers. Among the last published studies, one clinical study [Wiacek et al. 2024] and one preclinical study [Murack et al. 2024] demonstrated benefits on sleep. Particularly, Murack et al. 2024 study demonstrated new mechanistic findings on the modulation of sleep architecture and improvement in depressive-like behaviors in adolescent mice in sleep-disrupted conditions. Addition to that, one proof-of-concept study which was just published [Kassem et al. 2025], showed improvement on sleep circadian rhythm, perceived stress, but also on skin health, introducing the in and out well-being concept.

These scientific findings led to a better understanding of the benefits of this formula in modulating the physiological and psychological responses to occasional stress, allowing exclusive authority-approved health claims.

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Pioneering positive results on stress-related gut comfort in healthy population

In 2008, Diop et al. conducted the first study demonstrating the effect of a probiotic, Cerebiome, on stress-induced gastrointestinal symptoms in healthy adults. This double-blind, placebo-controlled, randomized clinical trial involved individuals experiencing frequent stress. Participants self-assessed their symptoms using a visual analog scale and were administered either a 3 billion CFU dose of Cerebiome daily or a placebo over three weeks. The results showed a significant 49% reduction in stress-induced gastrointestinal symptoms, such as abdominal pain and nausea in the Cerebiome group compared to the placebo group.

Positive impact on occasional stress in healthy population

In 2010, Messaoudi et al. conducted a groundbreaking clinical study on stressed but healthy adults to investigate the effects of probiotics on psychological stress. This double-blind, placebo controlled, randomized trial used validated psychological assessment scales and stress biomarker sampling, including a 24-hour urinary free cortisol test. Participants received either a 30-day supply of Cerebiome or a placebo. The results showed that daily consumption of Cerebiome significantly improved psychological signs related to occasional stress. This study provided compelling evidence of the gut-brain axis's role in stress reduction.

Holistic mental well-being with Cerebiome

It has been demonstrated that stress could have a significant impact on sleep quality. In 2024, Wiacek et al. conducted a randomized double blind pilot clinical study in 15 healthy dancers who tend to have psychological and physical stresses. They took either Cerebiome or placebo for 12 weeks. The results demonstrated a trend toward an improvement of sleep quality according to PSQI validated questionnaire.

Addition to that, one innovative clinical study of Kassem et al., which was newly published in 2025, showed first results on in-and-out wellbeing as assessed a significant improvement on perceived stress, sleep circadian rhythm but also on skin appearance. After 8 weeks intake of Cerebiome, 91% of the 35 women reported a satisfaction of the global performance of the probiotic and 79% of them experienced noticeable improvements in their mental wellbeing.

Cerebiome-iIs-a-Side-Effect-Free-and-Natural-Approach-to-Manage-Everyday-Stress-and-Promoting-Positive-Mood

Leveraging The Microbiome-Gut-Brain Axis

According to the World Health Organization (WHO), stress is a common health issue across the globe. In recent years, this health concern has been exacerbated, and half of people state they experience stress most of the time or all the time. Consequently, an increased number of consumers are proactively seeking natural solutions, such as dietary supplements and botanical extracts, to help manage their stress and mood in complement to a well-balanced diet and a healthy lifestyle to support mental wellness.

Since ancient times, Hippocrates claimed that ‘all disease begins in the gut’. Today, this wisdom resonates with modern research on the gut-brain axis. Often referred to as our ‘second brain,’ the gut plays a crucial role in our overall well-being. Starting in the 2000s, pioneering research has revealed compelling evidence of the dynamic communication between the gut and the brain. This interaction becomes particularly intense during periods of stress, whether due to significant life events, challenging exams, job changes, or pivotal meetings, leading to gut discomfort.

Sustained stress triggers a chain reaction in the body, affecting various systems, including gut comfort.

When stressed, the amygdala, the brain’s emotional control center, alerts the hypothalamus, the brain’s command center, which then activates the nervous system. This leads to the release of stress hormones like adrenaline and cortisol. These hormones prepare the body for the fight-or-flight response and causing physical symptoms such as a racing heart, muscle tension, elevated blood pressure, and rapid breathing. These physiological changes enhance strength, stamina, reaction time, and focus, preparing the body to confront or escape from the stressor.

Moreover, this intense reaction can compromise gut barrier’s integrity and upset the balance of gut microbiota. Face to this unbalance condition, the gut react by sending signals to the brain through vagus nerve. The brain interprete theses signals as new stressor, worsening the effects of external stressors and eventually resulting in psychological, physiological, and behavioral symptoms.

This chain reaction results in a vicious circle of stress response through the Microbiota-Gut-Brain axis.

Modes of Actions

How does Cerebiome works?

Cerebiome positively influences the microbiome-gut-brain axis through various mechanisms, leading to mental well-being improvement. Clinical studies have shown its benefits in reducing occasional stress and improvement of related conditions, such as gut comfort, sleep quality but also skin health, in healthy individuals. Additionally, eleven preclinical studies have demonstrated its positive impact on anxiety and depression-related behaviors in animal models.

These groundbreaking studies have enhanced our understanding of how Cerebiome works through eight modes of actions, collectively highlighting the multifaceted approach of Cerebiome in promoting mental and gut health, with promising implications for overall well-being.

1. Positive impact on behavior

In rodent models, Cerebiome significantly decreases depression-like behaviors. This is evidenced by the normalization of burying time, a marker associated with anxiety, and the restoration of social interaction time with other rats. Additionally, improvements in swimming and learning times have been observed. Recently, findings demonstrated a decreasing in sleep latency and increasing average of REM duration per bouts during sleep phase which are associated with a modulation in sleep architecture in sleep-disrupted adolescent mice [Messaoudi et al. 2010, Arseneault-Bréard et al. 2012, Gilbert et al. 2012, Murack et al. 2024].

2. Protection of a healthy brain structure and metabolism

Cerebiome helps maintain normal levels of neuroplasticity and neurosynthesis, crucial processes for brain health. Biomarkers such as caspase and BDNF or hippocampal energy sources such as glucose and L-lactate indicate its positive impact on these aspects [Girard et al. 2009, Gilbert et al. 2012, Malick et al . 2015, Ait-Belgnaoui et al. 2014, Mohammadi et al. 2018, Murack et al. 2024].

3. Prevention of neuroinflammation

Occasional neuroinflammation in the limbic system, a brain region linked to stress response, is mitigated by Cerebiome [Mohammadi et al. 2018].

4. Modulation of the hypothalamus-pituitary adrenal Axis

Cerebiome helps maintain healthy cortisol levels, a key hormone linked to stress, in both humans and animals [Messaoudi et al. 2010, [Ait-Belgnaoui et al. 2014, 2018; Malick et al. 2015].

5. Synthesis of neurotransmitters and their precursors

This probiotic formula normalizes blood neurotransmitters levels in rats and increases neurotransmitter precursors in both rats and humans. Even more, it restores serotonin level and its precursor tryptophan in sleep-disrupted mice. [Tillman et al. 2018, Kazemi et al. 2018, De Oliveira et al. 2023, Murack et al. 2024].

6. Modulation through the vagus nerve

The probiotic formula decreases apoptosis, the naturally occurring cell death process during growth. This mechanism relies on an intact vagus nerve. [Malick et al. 2015].

7. Protection of the intestinal barrier/decreased visceral pain

Cerebiome showed a reduction in intestinal permeability in rats’ model and a decreasing in visceral pain in mice, promoting gut comfort. [Arseneault-Bréard et al. 2012 & Ait-Belgnaoui et al. 2018].

8. Cytokine modulation

Cerebiome showed a reduction of proinflammatory biomarkers induced by stress, as evidenced by biomarker assessments such as cytokine IL-1β and TNF-α. [Malick et al. 2015, Arseneault-Bréard et al. 2012, Mohammadi et al. 2018].

Benefits as adjunct therapy in participants with depression*

Why chose Cerebiome by Lallemand: The best probiotic for mental health

Approved health claims on mental health

All study findings have led to official recognition from Canadian and Brazilian health authorities. Cerebiome is the first psychobiotic with specific approved health claims on mood and stress. This recognition from competent authorities adds tremendous value and indicates that the scientific evidence supporting this psychobiotic are robust and verifiable.

Safe, stable and reliable ingredient

Marketed in more than 40 finished products worldwide, alone or with other ingredients, Cerebiome offers a particularly good shelf-life stability even at room temperature. This formula is available in various dosage formats (powder, capsules, tablets, sachets/sticks) and can be microencapsulated with Lallemand Health Solutions patented technology. Research and development teams are working to create innovative formulas with Cerebiome and other added-value ingredients such as botanical extracts, prebiotics, bacteria, yeast, vitamins, and minerals

A unique formulation’s expertise

Lallemand Health Solutions cumulates 90+ years of microbial fermentation production know-how from lab to shelf, Lallemand Health Solutions has the full control and expertise to produce premium tailored-made probiotic formulations in state-of-the-art facilities certified for the highest quality.

Unlocking the Gut-Brain axis with Cerebiome: Probiotic for Mental Health

In this enlightening video, dive into the fascinating world of Cerebiome, a groundbreaking probiotic redefining mental health support. Discover how Cerebiome functions uniquely, shedding light on its distinct modes of action and the scientific evidence behind its impact. Join us to unravel the innovative potential of this probiotic and its implications for nurturing a healthier mind.

Cerebiome exerts a positive influence on the gut microbiota

This short video illustrates how researchers have tracked our psychobiotic Cerebiome® in a dynamic replica of the human gastrointestinal tract. With The Simulator of the Human Intestinal Microbial Ecosystem (SHIME®) model they demonstrate the positive influence of Cerebiome® on neurotransmitters and microflora balance.

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Discover Cerebiome®: The Most Documented Psychobiotic