Probiotics For Mental Health

Psychobiotics: For a Balanced Microbiome-Gut-Brain Axis

Now considered in many countries as a mainstream probiotic application, mental health is influenced by the gut-brain connection. The communication between the gut and the brain is bidirectional and intensifies in times of stress. Psychological stress can impact the gastroenteric well-being, and vice versa.

Recently, the microbiome has been recognized as a third interlocutor in this relation and the microbiome-gut-brain axis concept has emerged. The microbiome-gut-brain axis is increasingly studied in regulating stress-related responses. Lallemand Health Solutions is a pioneer in the field of psychobiotics. Since 1929, we have been researching and developing probiotic solutions for mental health. New opportunities in stress management through the gut-brain axis are coming forth, such as the use of psychobiotics like Cerebiome^® (L. helveticus Rosell^®-52 and B. longum Rosell^®-175).

Cerebiome^® is a pioneering psychobiotic with game-changing science and a 20-year history of safe use. It is the most documented probiotic to support a healthy response to everyday occasional stress. Already in 2008, a study showed that Cerebiome^® significantly reduced gut disturbances induced by psychological stress in healthy people.

In 2010, a pioneering clinical study was published showing that Cerebiome® significantly decreased the feelings of occasional psychological stress in healthy volunteers [Messaoudi, 2010]. This gold-standard clinical study was a huge step for the gut-brain axis and used as an important reference in literature.

Now, Cerebiome has demonstrated benefits not only in gut comfort and occasional stress but also in holistic well-being such as sleep quality, which is perfectly aligned with the evolving needs of consumers [FMCG Gurus survey 2024, Emotional well-being]. Among recently published studies, one clinical study [Wiacek, 2024] and one preclinical study [Murack, 2024] demonstrated benefits on sleep. Particularly, Murack et al. 2024 study demonstrated new mechanistic findings on the modulation of sleep architecture and in depressive-like behaviors in adolescent mice in sleep-disrupted conditions. Additionally, a recently published proof-of-concept study [Kassem, 2025], demonstrated benefits on sleep circadian rhythm, perceived stress, but also on skin health, introducing the in-and-out well-being concept, reflecting improvements in both internal physiological functions and visible external benefits.

Beyond mood and occasional stress support, Cerebiome has been studied in an innovative clinical study exploring the effects of Cerebiome® on cognition, specifically attention-related measurements, in healthy young adults playing action video games [Monroe et al. – manuscript in preparation].
The preliminary results* in key attention related cognitive parameters, reaction time and processing speed are promising. This further expands the scope of Cerebiome®, opening new perspectives in cognitive health.

Cerebiome® is part of the Expert’Biotic offer, which includes other innovative probiotic solutions for the microbiota-gut-brain axis. B. bifidum Rosell®-71, can help students cope with academic stress and L. rhamnosus HA-114 has a demonstrated effect on cognitive health and age-dependent neurodegeneration.

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