News details

Probio’stick in a neuroinflammation rat model

Promising study on Probio’Stick in a neuroinflammation model in rodents

In recent years, the brain-gut axis has gained momentum with the discovery of the importance and complexity of the gut microbiota.

LHS pioneered the first-ever clinical study on the Brain-Gut Axis in healthy adults, showing for the first time in 2010 the positive effects of a probiotic formula on psychological occasional stress with Probio’Stick. This specific probiotic formula is demonstrated to promote positive mood in stressful events. It can help moderate physiological (Diop 2008) and psychological (Messaoudi 2010, 2011) responses to occasional stress.

Probio’Stick modes of action have been documented by 9 mechanistic studies showing in particular that:

  • Benefits are partly mediated through the vagal nerve, but local benefits persist (Malik 2015)
  • Stress-induced damages are prevented in the brain (Ait-Belgnaoui 2014)
  • Both strains work synergistically (Ait Belgnaoui 2018)

This month, a new mechanistic study has been published on a model of neuroinflammation in rats. Probio’stick administration prior LPS-induced neuroinflammation has a significant protective effect on neurogenesis, neuroinflammation and systemic inflammation.